Post by atin1 on Nov 3, 2016 21:06:45 GMT
For a sample size of 2550, I got the following estimates for genetic correlation. The traits were inverse normal transformed. No error message from GCTA.
A genetic correlation of -1 seems off.
Also the heritability estimate for the 2 traits estimated separately is about 5% higher than the estimates in genetic correlation output.
I'd appreciate some advice on interpreting the results below.
Thanks
Genetic correlation output
--------------------------------
Source Variance SE
V(G)_tr1 0.426155 0.180676
V(G)_tr2 0.110520 0.140791
C(G)_tr12 -0.217022 0.122279
V(e)_tr1 0.563583 0.179170
V(e)_tr2 0.895291 0.142906
C(e)_tr12 0.304515 0.122345
Vp_tr1 0.989737 0.027718
Vp_tr2 1.005811 0.028235
V(G)/Vp_tr1 0.430573 0.181366
V(G)/Vp_tr2 0.109881 0.139935
rG -1.000000 0.945005
Heritability estimate for trait 1
------------------------------------
Summary result of REML analysis:
Source Variance SE
V(G) 0.491746 0.179405
V(e) 0.503243 0.177201
Vp 0.994990 0.027960
V(G)/Vp 0.494223 0.178665
Heritability estimate for trait 2
------------------------------------
Source Variance SE
V(G) 0.167853 0.148468
V(e) 0.833640 0.149601
Vp 1.001493 0.028060
V(G)/Vp 0.167603 0.148067
A genetic correlation of -1 seems off.
Also the heritability estimate for the 2 traits estimated separately is about 5% higher than the estimates in genetic correlation output.
I'd appreciate some advice on interpreting the results below.
Thanks
Genetic correlation output
--------------------------------
Source Variance SE
V(G)_tr1 0.426155 0.180676
V(G)_tr2 0.110520 0.140791
C(G)_tr12 -0.217022 0.122279
V(e)_tr1 0.563583 0.179170
V(e)_tr2 0.895291 0.142906
C(e)_tr12 0.304515 0.122345
Vp_tr1 0.989737 0.027718
Vp_tr2 1.005811 0.028235
V(G)/Vp_tr1 0.430573 0.181366
V(G)/Vp_tr2 0.109881 0.139935
rG -1.000000 0.945005
Heritability estimate for trait 1
------------------------------------
Summary result of REML analysis:
Source Variance SE
V(G) 0.491746 0.179405
V(e) 0.503243 0.177201
Vp 0.994990 0.027960
V(G)/Vp 0.494223 0.178665
Heritability estimate for trait 2
------------------------------------
Source Variance SE
V(G) 0.167853 0.148468
V(e) 0.833640 0.149601
Vp 1.001493 0.028060
V(G)/Vp 0.167603 0.148067
