Post by weihuameng on Nov 25, 2014 15:52:56 GMT
I am calculating narrow sense heritability for a cases-control GWAS study using genotyped SNPs. qualitative trait.
My question is why the heritability of the overall dataset (0.117) is lower than female dataset (0.167) and male dataset (0.28)? I guess it has something to do with the overalll sample size is bigger ? But can anyone provide more scientific explanations? Thank you a lot.
For the over all dataset: h2= 0.117
Source Variance SE
V(G) 0.019111 0.009623
V(e) 0.144592 0.009931
Vp 0.163704 0.003420
V(G)/Vp 0.116743 0.058626
For female dataset:h2=0.167
Source Variance SE
V(G) 0.032089 0.026904
V(e) 0.160390 0.027125
Vp 0.192480 0.006345
V(G)/Vp 0.166716 0.139428
For male only dataset:h2 = 0.285
Source Variance SE
V(G) 0.040967 0.014298
V(e) 0.102580 0.014207
Vp 0.143547 0.003887
V(G)/Vp 0.285393 0.098667
My question is why the heritability of the overall dataset (0.117) is lower than female dataset (0.167) and male dataset (0.28)? I guess it has something to do with the overalll sample size is bigger ? But can anyone provide more scientific explanations? Thank you a lot.
For the over all dataset: h2= 0.117
Source Variance SE
V(G) 0.019111 0.009623
V(e) 0.144592 0.009931
Vp 0.163704 0.003420
V(G)/Vp 0.116743 0.058626
For female dataset:h2=0.167
Source Variance SE
V(G) 0.032089 0.026904
V(e) 0.160390 0.027125
Vp 0.192480 0.006345
V(G)/Vp 0.166716 0.139428
For male only dataset:h2 = 0.285
Source Variance SE
V(G) 0.040967 0.014298
V(e) 0.102580 0.014207
Vp 0.143547 0.003887
V(G)/Vp 0.285393 0.098667
