Now I have 51 SNPs, with allele frequency of targeted population and odd ratio (reported in GWAS) to the phenotype (a disease). Can I use the allele frequency and its odd ratio to simulate the phenotype distribution in a given population size? For example, assuming population size (n=500), in the first time point, there will be 50 disease/250 control. And in the second time point, the allele frequency changed, so there will be 60 disease/240 control. So I can say if n=500, 10 increased diseases are due to the changes of allele frequency? Can anyone know any tool to do this? Any suggestions and comments are welcomed.
Erping Long Ph.D candidate University of Michigan Email: email@example.com