Post by irene on Oct 3, 2013 12:32:00 GMT
Dear all,
a conceptual issue: Is there a difference between estimating heritability by using GCTA and estimating variance explained by common SNPs?
I am asking because I am interested to know if I should use the filter of close relatedness (>0.025) or not?
If I don't exclude those relatives (closer than 3rd cousins), will I have a problem estimating the narrow sense heritability in my sample?
Or is this filter should be used only in the case I want to estimate proportion of variance explained by common SNPs?
Any idea/ suggestion is more than welcome!
a conceptual issue: Is there a difference between estimating heritability by using GCTA and estimating variance explained by common SNPs?
I am asking because I am interested to know if I should use the filter of close relatedness (>0.025) or not?
If I don't exclude those relatives (closer than 3rd cousins), will I have a problem estimating the narrow sense heritability in my sample?
Or is this filter should be used only in the case I want to estimate proportion of variance explained by common SNPs?
Any idea/ suggestion is more than welcome!
