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Post by aazaidi on Mar 16, 2020 15:42:46 GMT
Hi,
I'm trying to run fastGWA on simulated data and I have two questions:
1. Does it estimate h2g after regressing out covariates in the first step?
2. I noticed that it runs a simple linear regression instead of the mixed model when it estimates heritability that is not significantly different from zero. Is there a way to force it to run the MLM in this case?
I'm interested because I am simulating traits with nonzero heritability with environmental stratification and after including PCs as fixed effects, the heritability goes to zero because it's being soaked up by the PCs.
Thank you, Arslan
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