Post by Jorien on May 25, 2020 8:14:28 GMT
Hi!
I have a question about the standardization step of GSMR as described at cnsgenomics.com/software/gsmr/.
The instructions state that the input should be allele frequencies, z-statistics and sample size. Could you please clarify what is meant exactly with
z-statistics here? I assume it is not standardized, z-scores, as the script also requires you to include SEs.
In my case, the unit of the effect size I have is an unstandardized beta (a volume measure), would it be correct if I input these unstandardized betas and use
the standardization step to get to a standardized beta?
Thank you in advance!
I have a question about the standardization step of GSMR as described at cnsgenomics.com/software/gsmr/.
The instructions state that the input should be allele frequencies, z-statistics and sample size. Could you please clarify what is meant exactly with
z-statistics here? I assume it is not standardized, z-scores, as the script also requires you to include SEs.
In my case, the unit of the effect size I have is an unstandardized beta (a volume measure), would it be correct if I input these unstandardized betas and use
the standardization step to get to a standardized beta?
Thank you in advance!
