Post by jcli on Mar 1, 2021 21:13:09 GMT
Hello,
I am thinking of applying MTCOJO to do conditional analysis to some summary stats data that I have. This might be a simple question but from reading papers/documentation out there I could not immediately find the answer.
I have three traits, A B and C, and want to condition on the effect of C.
When running the analysis, what is the correct way to run MTCOJO?
Should I run it for A condiitoned by C and then B conditioned by C and then do a LDSC of the two resulting files?
Or is it enough to do the conditioning on one file A and then do LDSC with the conditioned A results and original B?
I've tried both, and the results are very similar, but I was just wondering what was correct.
Thank you in advance for your help!!
I am thinking of applying MTCOJO to do conditional analysis to some summary stats data that I have. This might be a simple question but from reading papers/documentation out there I could not immediately find the answer.
I have three traits, A B and C, and want to condition on the effect of C.
When running the analysis, what is the correct way to run MTCOJO?
Should I run it for A condiitoned by C and then B conditioned by C and then do a LDSC of the two resulting files?
Or is it enough to do the conditioning on one file A and then do LDSC with the conditioned A results and original B?
I've tried both, and the results are very similar, but I was just wondering what was correct.
Thank you in advance for your help!!