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Post by johannfaouzi on May 10, 2021 12:19:51 GMT
Hi,
I was wondering if it is possible to run SBLUP by providing the LD matrix from a reference sample instead of a reference sample with individual-level data.
Having a reference sample with individual-level data is not always trivial and, when computing many polygenic risk scores for a given population, not having to re-estimate the LD matrix every time sounds much more efficient.
Best regards, Johann Faouzi
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