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Post by mszzeta on Dec 22, 2022 2:24:18 GMT
Hi I used COJO to perform stepwise model selection (--cojo-slct) with --cojo-p 5e-8 on a meta-analysis summary statistics. I found that ~10-15% SNPs selected had non-significant p values (p > 5e-8) but with joint model p value < 5e-8. For a few SNPs, the GWAS p values and joint model p are even very different. I wonder what the problem might be?
Thank you very much!
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