mac76
New Member
Posts: 4 
|
Post by mac76 on Jun 7, 2014 10:35:45 GMT
Is it possible to run a bivariate MLM on let's say height between two samples where you only have height measure within each sample but no overlapping height measure? GRM for all individuals is available.
|
|
|
|
Post by Jian Yang on Jun 7, 2014 12:08:06 GMT
GCTA can actually deal with data from non-overlapping samples. You can
specify the phenotype file as
FID IID Tr1 Tr2
1 11 0.5 NA
2 21 0.2 NA
3 31 0.1 NA
...
98 981 NA 0.4
99 991 NA 0.1
100 1001 NA 0.1
The GRM should be constructed from all samples combined.
|
|
mac76
New Member
Posts: 4
|
Post by mac76 on Jun 9, 2014 12:54:37 GMT
Thank you Jian. I eventually worked it out. I was having problems as I was trying to use fixed covariates which also did not overlap and as it turned out I couldn't use them. Instead I regressed each sample on its respective fix effect covariates and all worked fine. Again thank you very much for your quick response.
|
|
