MLM using pre-computed GRM

st Guest	MLM using pre-computed GRM Jun 19, 2014 1:30:57 GMT Quote Select Post Deselect Post Link to Post Back to Top Post by st on Jun 19, 2014 1:30:57 GMT Is it possible to use a previously computed genetic relationship matrix to do mixed linear model association in GCTA? Could this speed up the analysis, especially in a dataset with a large number of tested variants?

Jian Yang Administrator Posts: 362	MLM using pre-computed GRM Jun 19, 2014 2:03:18 GMT Quote Select Post Deselect Post Link to Post Member Give Gift Back to Top Post by Jian Yang on Jun 19, 2014 2:03:18 GMT Yes, it will speed up the analysis. Example # MLM based association analysis - If you have already computed the GRM gcta64 --mlma --bfile test --grm test --pheno test.phen --out test --thread-num 10