Post by hnorpois on Jun 23, 2014 15:02:28 GMT
Hello,
there are 2 ways to do a partioning of genomic variation by chromosome - separate and joint analysis. In Lee et al 2012 (Estimating the proportion of variation in susceptibility ...) it is mentioned : "... we performed two kinds of analyses: one in which the similarity matrix for each chromosome was fitted separately (22 analyses estimating one additive genetic variance component per analysis) and a second joint analysis in which the 22 similarity matrices were fitted simultaneously (estimating 22 additive genetic variance components in a single analysis)."
Young et al 2011 (Genome Partioning):
"The joint analysis has the advantage of protecting against such inter-chromosomal correlations because the estimate of each is conditional on the other chromosomes in the model so that the estimates of variance explained by different chromosomes are independent of each other."
How is this done?
Can anybody please comment on the differences between separated and joint analysis? And what is the corresponding gcta64 syntax?
Thanks
Hermann Norpois
there are 2 ways to do a partioning of genomic variation by chromosome - separate and joint analysis. In Lee et al 2012 (Estimating the proportion of variation in susceptibility ...) it is mentioned : "... we performed two kinds of analyses: one in which the similarity matrix for each chromosome was fitted separately (22 analyses estimating one additive genetic variance component per analysis) and a second joint analysis in which the 22 similarity matrices were fitted simultaneously (estimating 22 additive genetic variance components in a single analysis)."
Young et al 2011 (Genome Partioning):
"The joint analysis has the advantage of protecting against such inter-chromosomal correlations because the estimate of each is conditional on the other chromosomes in the model so that the estimates of variance explained by different chromosomes are independent of each other."
How is this done?
Can anybody please comment on the differences between separated and joint analysis? And what is the corresponding gcta64 syntax?
Thanks
Hermann Norpois
