Post by kzar0004 on Aug 17, 2016 7:34:05 GMT
Dear gcta,
I have a question regarding my REML output. In the output below the phenotype I used was results from a cognitive examination for n=162 subjects.
Source Variance SE
V(G) 52.372958 26.878553
V(e) 34.147764 24.054993
Vp 86.520722 9.958276
V(G)/Vp 0.605323 0.285860
logL -439.013
logL0 -440.225
LRT 2.422
df 1
Pval 0.06
n 162
Is it correct to interpret from the above that 60% of the variance observed in the cognitive scores is explained by all the SNPs?
Furthermore I am slightly confused by how to understand the "Pval 0.06". In the GCTA homepage under section: GCTA-GREML: estimation of the phenotypic variance explained by the SNPs, point number '5' , the explanation of the P val is missing... How can the genetic variation explain 60% of the variation seen in the phenotype (cognitive exam) but this not yield a significant P val?
Also, in your homepage you write "If there are multiple GRMs included in the REML analysis, there will be multiple rows for the genetic variance ..."
Why would there be multiple GRMs?
I have a question regarding my REML output. In the output below the phenotype I used was results from a cognitive examination for n=162 subjects.
Source Variance SE
V(G) 52.372958 26.878553
V(e) 34.147764 24.054993
Vp 86.520722 9.958276
V(G)/Vp 0.605323 0.285860
logL -439.013
logL0 -440.225
LRT 2.422
df 1
Pval 0.06
n 162
Is it correct to interpret from the above that 60% of the variance observed in the cognitive scores is explained by all the SNPs?
Furthermore I am slightly confused by how to understand the "Pval 0.06". In the GCTA homepage under section: GCTA-GREML: estimation of the phenotypic variance explained by the SNPs, point number '5' , the explanation of the P val is missing... How can the genetic variation explain 60% of the variation seen in the phenotype (cognitive exam) but this not yield a significant P val?
Also, in your homepage you write "If there are multiple GRMs included in the REML analysis, there will be multiple rows for the genetic variance ..."
Why would there be multiple GRMs?
