Post by zuoxy on Sept 25, 2015 8:57:48 GMT
Hi,
I want to estimate the variance explained by X chromosome for males and females separately to see whether the X chromosome had discrepancy of contribution on disease susceptibility between males and females. Since the X-inactivation models made thing a little complicated, I am not sure that how to separately assess the contribution of X chromosome on heritability for males and females, respectively. In intuitive, X chromosome for female could be treated as an autosome. Is it proper if I included only males and assign different dosage compensation model ?
Best regards,
xiaoyu zuo
I want to estimate the variance explained by X chromosome for males and females separately to see whether the X chromosome had discrepancy of contribution on disease susceptibility between males and females. Since the X-inactivation models made thing a little complicated, I am not sure that how to separately assess the contribution of X chromosome on heritability for males and females, respectively. In intuitive, X chromosome for female could be treated as an autosome. Is it proper if I included only males and assign different dosage compensation model ?
Best regards,
xiaoyu zuo
