Post by lulipe on Jan 26, 2016 16:43:17 GMT
Hi everyone!
I would like to do an analysis similar to the one proposed by Zaitlen et al. (2013), estimating narrow-sense heritability and heritability explained by genotyped SNPs with family data from a GWAS.
I've already read the relevant publications. Now, I am wondering about the exact assumptions for using GCTA in the above setting:
* Residuals and random effects are supposed to be normal. How can you check that?
* What about continuous phenotypes... Do they have to be normal as well?
I would be really glad to read some words about that as it hasn't been covered either in the FAQ nor in this Forum.
Thank you very much in advance!
I would like to do an analysis similar to the one proposed by Zaitlen et al. (2013), estimating narrow-sense heritability and heritability explained by genotyped SNPs with family data from a GWAS.
I've already read the relevant publications. Now, I am wondering about the exact assumptions for using GCTA in the above setting:
* Residuals and random effects are supposed to be normal. How can you check that?
* What about continuous phenotypes... Do they have to be normal as well?
I would be really glad to read some words about that as it hasn't been covered either in the FAQ nor in this Forum.
Thank you very much in advance!