Negative values found in genetic correlation matrix

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xyyin666666
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Posts: 9

Negative values found in genetic correlation matrix Mar 16, 2016 19:04:24 GMT

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Post by xyyin666666 on Mar 16, 2016 19:04:24 GMT

Hi there,

I used the GCTA to estimate the genetic relationship matrix in my GWAS imputed + genotype data. In the genetic relationship matrix, I found a lot of negative values. I thought the correlation should be positive. How could it be negative?

Thanks,

Jian Yang Administrator Posts: 362	Negative values found in genetic correlation matrix Mar 26, 2016 4:50:28 GMT Quote Select Post Deselect Post Link to Post Member Give Gift Back to Top Post by Jian Yang on Mar 26, 2016 4:50:28 GMT If there is no population structure in the sample, the expected value of GRM is zero (Yang et al. 2010 NG). The negative values are expected.
	Last Edit: Mar 26, 2016 4:50:51 GMT by Jian Yang

Negative values found in genetic correlation matrix

Post by xyyin666666 on Mar 16, 2016 19:04:24 GMT

Post by Jian Yang on Mar 26, 2016 4:50:28 GMT