bn
New Member
Posts: 6
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Post by bn on May 27, 2016 8:40:44 GMT
Hello, We are analysing the association of rare variants in our phenotype with the ExomeChip data of 35,000 individuals in the discovery phase. We have some strong associations and would like to perform a conditional analysis on a particular SNP in our individuval cohort of 5000 samples. Would GCTA work for rare variants ?
The command I am using is
gcta64 --bfile cohort1 --cojo-actual-geno --chr $chr --maf 0.000001 --cojo-file discovery_summarystats.ma --cojo-cond snplist --out conditionedSNP
Many thanks.
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Post by Jian Yang on Jun 3, 2016 4:58:44 GMT
Yes, in principle. I would suggest you remove the --cojo-actual-geno (although you have used the actual genotypes as reference for LD estimation) which would be a bit conservative but you would not have over fitting problem.
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