Post by soren on Jun 12, 2024 16:47:22 GMT
Hello,
I have been trying to run the analysis to achieve a result around .30 - .40 but have been failing to lower the V(G)/Vp despite genetic cut-off, elimination of cryptic relatedness.
I have my phenotype file in the following format
IID FID CASE/CONTROL
My phenotype file (--pheno) is 4490 lines long with 1184 cases and 3306 controls.
I am making my grm using binary data which has SNP data.
I am also adjusting the prevalence of the disease I am working towards and --maf is 0.01.
What are the factors that are causing the genetic variance to be .99 ?
I have been trying to run the analysis to achieve a result around .30 - .40 but have been failing to lower the V(G)/Vp despite genetic cut-off, elimination of cryptic relatedness.
I have my phenotype file in the following format
IID FID CASE/CONTROL
My phenotype file (--pheno) is 4490 lines long with 1184 cases and 3306 controls.
I am making my grm using binary data which has SNP data.
I am also adjusting the prevalence of the disease I am working towards and --maf is 0.01.
What are the factors that are causing the genetic variance to be .99 ?